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    Source: Rectal cancer markers - Physiology.

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    Old fashion chemotherapy has so many adverse effects and the survival rates became steady for the last decades. Efforts were made in two other directions prevention of rectal cancers by large population screenings, and the other was research of intimate mechanism of rectal cancer progression and identifying new markers for better targeted new anti-cancer drugs.

    We intend to emphasize the role of angiogenesis markers in actual stage of research in order to settle new goals for our research.

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    We identified three possible paths in evaluation of the rectal cancer angiogenesis suitable for our research: microvessel density quantified by CD34 and CD, morphometric analysis of the intratumor and peritumor vessel marked with CD34 and CD in order to achieve new patterns of progressing for rectal cancer, and a combined analyses of VEGF and podoplanin. The biological behaviour of rectal cancers is tailored by many factors, most of them activating different rectal cancer markers of vascular growth.

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    Reasearch should focus on the relation between these factors and finding new ways of targeting multiple factors during chemotherapy in order to restrict tumor blood supply by slowing the angiogenesis. Copyright of Fiziologia - Physiology is the property of Romanian Society of Physiological Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission.

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    This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.

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