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How to measure toxicity in body

By measuring subtle changes in the tissues, fluids, and blood vessels of the eyes, it can detect health problems without contact.

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Image right: Probe being tested at the National Institutes of Health. Credit: NASA Glenn researcher Rafat Ansari first incorporated the technology into a fiber-optic probe to look for cataracts, which occur when proteins in the lens of the eye gradually clump and eventually cloud the lens. Worldwide, cataracts cause 50 percent of blindness.

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They are caused by aging, disease especially diabetessmoking, dehydration, malnutrition, and ultraviolet light. Surgery is the only treatment currently available--resulting in 1.

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In space, the exposure of astronauts to even relatively low doses of ultraviolet light and ionizing radiation can accelerate aging and cataract formation. Often cataracts are not discovered until vision has already been impaired. Manual B. Diagnosing cataracts at such an early stage will allow researchers to study ways to treat them nonsurgically.

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The probe is also being used to check for abnormalities in the cornea of the eye before LASIK surgery which is used to correct nearsightedness. The probe is compact, portable and rugged, with point-and-shoot operation.

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It gives extremely sensitive, accurate particle-sizing measurements during a safe, short eye examination 2 to 20 seconds using low laser radiation 10 nanowatts to 3 milliwattsand there is no physical contact with the eye.

In laboratory tests, it can be used with many sample container sizes, materials, and shapes. Image left: "Space Goggles" being developed to monitor the health of astronauts.

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It uses various forms of light to diagnose and monitor diseases of the eye and of the entire body. Viermele de galbeaza Ansari and Marco Cabrera Case Western Reserve University and University Hospitals of Cleveland are working on this powerful, compact device, which will integrate several noninvasive technologies into one portable, easy-to-use piece of equipment. The system includes miniaturized fiberoptic probes to collect data, a computer for data analysis, and Internet connectors to transmit the data to NASA's Mission Control.

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It combines lasers, detectors, a correlator, and a spectrum analyzer into a single unit to meet the requirements of different diagnostic technologies.

Space Goggles use dynamic light scattering to detect cataracts, radiation damage, diabetes, eye inflammation, cholesterol levels, Alzheimer's, and environmental toxicity.

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The goggles use corneal autofluorescence, laser Doppler velocimetry, Raman spectroscopy, and polarimetry to detect diabetic retinopathy, age-related macular degeneration, and blood glucose sugar levels. Reflectometry, oximetry, optical coherence tomography, and a scanning laser ophthalmoscope may be added later. Tests can be done quickly, remotely, without discomfort, and in real time.

Early detection and monitoring of two of these diseases--diabetes and Alzheimer's--would be especially helpful. Sixteen million Americans have diabetes mellitus, and millions more have undiagnosed diabetes, which increases the risks of complications such as cataracts, diabetic retinopathy, glaucoma, limb amputations, and kidney disease.

Because the amount of glucose in a solution changes the rotation of linearly polarized light and because the how to measure toxicity in body of glucose in the aqueous humor of the eye closely matches blood glucose levels, the probe can accurately measure blood glucose levels without skin pricks or even contact.

Diabetes could be diagnosed earlier, treatment could be started earlier, and blood glucose monitoring could be done painlessly and more frequently, improving diabetes control.

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Alzheimer's disease is characterized by protein deposits called amyloids that are found in the brain. Currently, these can only be found when an autopsy is performed after death.

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Before that, the diagnosis is uncertain. However, because these proteins are also deposited in pastile pentru ficat si slabit parts of the eye, dynamic light scattering could be adapted to diagnose Alzheimer's disease much earlier, allowing how to measure toxicity in body better research and earlier treatment with anti-inflammatories, anti-oxidants, hormones or other drugs to possibly delay the disease.

Such an instrument could be used during a routine eye exam to detect early signs of health problems, and blood glucose and cholesterol levels could be measured without blood samples. With such an advanced warning system, researchers could study the effectiveness of experimental drugs and therapies.

In addition, it could be used on Earth to diagnose medical problems in remote settings.

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If your company is interested in taking advantage of this or other technologies, contact Glenn's Technology Transfer and Partnership Office. More information:.